Cannabidiol Shows Promise in Treating Mucosal Diseases

Cannabidiol (CBD), a non-psychoactive compound derived from cannabis, continues to capture the interest of the medical community due to its wide-ranging potential therapeutic benefits. Notably, recent research has shown its efficacy in managing certain types of drug-resistant epilepsies and has hinted at potential benefits for anxiety, chronic pain, and inflammatory disorders based on animal studies.

Despite being traditionally restricted, regulatory stances on CBD are softening, a shift driven by both its growing use in consumer products and mounting evidence supporting its safety and therapeutic properties. Currently, Epidiolex® is the only CBD product approved by both the Australian Therapeutic Goods Administration and the US Food and Drug Administration.

Emerging studies suggest that CBD could also play a significant role in treating mucosal diseases, particularly those affecting the gut and lungs. Research conducted in vitro has demonstrated promising results, though the compound’s physical and chemical properties have proven challenging for effective use in in vivo and clinical trials.

The review also highlights ongoing efforts to enhance CBD’s delivery and efficacy through advanced formulations and technologies, such as self-emulsifying emulsions and nano- and microparticles. These innovations aim to bypass the obstacles posed by CBD’s inherent properties, potentially opening the door to new therapeutic applications.

The paper identifies significant research gaps and hurdles in the development of CBD-based treatments, urging further studies to explore and refine these novel delivery methods. This ongoing research is critical as it continues to unravel the complexities of CBD and its potential as a versatile therapeutic agent.

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